Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans
Name
Hallem-2011-Jan-Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.pdf
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1.43 MB
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Checksum (MD5)
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Author(s)
Hallem, Elissa A.
Spencer, W. Clay
McWhirter, Rebecca D.
Zeller, Georg
Henz, Stefan R.
Rätsch, Gunnar
Miller, David M., III
Sternberg, Paul W.
Ringstad, Niels
Horvitz, Howard Robert
Date Issued
December 2010
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Hallem, E. A. et al. “Receptor-type Guanylate Cyclase Is Required for Carbon Dioxide Sensation by Caenorhabditis Elegans.” Proceedings of the National Academy of Sciences 108.1 (2010) : 254-259.
Version
Final published version
Abstract
CO2 [CO subscript 2] is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO2 [CO subscript 2] avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO2 [CO subscript 2] specifically activates the BAG neurons and that the CO2-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO2 [CO subscript 2] sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO2 [CO subscript 2].
MIT Department
Massachusetts Institute of Technology. Department of Biology
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1017354108
