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Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo

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Author(s)
Leboeuf, Dominique
•
Abakumova, Tatiana
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Prikazchikova, Tatiana
•
Rhym, Luke
•
Anderson, Daniel G
•
Zatsepin, Timofei S
•
Piatkov, Konstantin I
Date Issued
2020
Journal
Molecular Therapy
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The American Society of Gene and Cell Therapy With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the Arg/N-degron pathway in a murine hepatocellular carcinoma model, Leboeuf et al. demonstrated potentiated action of chemotherapy. Since components of this pathway are ubiquitously expressed, targeting the N-degron pathway has the potential to increase effectiveness of therapy in many cancer types.
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DOI of Published Version
10.1016/J.YMTHE.2020.01.021
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