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Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo
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Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo
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1-s2.0-S1525001620300538-main.pdf
Description
Published version
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3.01 MB
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Adobe PDF
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sword-2021-06-03T17:33:37.original.xml (130 B)
Original SWORD entry document
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Author(s)
Leboeuf, Dominique
•
Abakumova, Tatiana
•
Prikazchikova, Tatiana
•
Rhym, Luke
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Anderson, Daniel G
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Zatsepin, Timofei S
•
Piatkov, Konstantin I
Date Issued
2020
Journal
Molecular Therapy
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The American Society of Gene and Cell Therapy With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the Arg/N-degron pathway in a murine hepatocellular carcinoma model, Leboeuf et al. demonstrated potentiated action of chemotherapy. Since components of this pathway are ubiquitously expressed, targeting the N-degron pathway has the potential to increase effectiveness of therapy in many cancer types.
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Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
http://creativecommons.org/licenses/by-nc-nd/4.0/
Persistent DSpace Link
https://hdl.handle.net/1721.1/136300
DOI of Published Version
10.1016/J.YMTHE.2020.01.021
