Role of adult neurogenesis in hippocampal-cortical memory consolidation
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1756-6606-7-13.pdf
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507.03 KB
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417c6260ce9a5452250f0ab528991986
Author(s)
Kitamura, Takashi
Inokuchi, Kaoru
Date Issued
February 2014
Journal
Molecular Brain
Publisher
BioMed Central Ltd
Citation
Kitamura, Takashi, and Kaoru Inokuchi. “Role of Adult Neurogenesis in Hippocampal-Cortical Memory Consolidation.” Molecular Brain 7.1 (2014): 13.
Version
Final published version
Abstract
Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/1756-6606-7-13
