Thermal-based probe for testing endothelial dysfunction and possible implications for diagnosing atherosclerosis
Name
77564678-MIT.pdf
Description
Full printable version
Size
3.38 MB
Format
Adobe PDF
Checksum (MD5)
99a6fcf60b0496960041ed4e6c3769e6
Author(s)
Lediju, Muyinatu A. (Muyinatu Adebisi)
Advisor(s)
H. Frederick Bowman.
Date Issued
2006
Publisher
Massachusetts Institute of Technology
Abstract
Endothelial dysfunction is a precursor to atherosclerosis. Thus, the vascular health of an individual can be assessed if endothelial dysfunction can be readily and unambiguously quantified. A thermal-based approach using temperature and blood perfusion measurements in conjunction with an arterial challenge has the potential to quantitatively assess endothelial dysfunction. This report includes a detailed review of previous attempts to characterize endothelial dysfunction and a preliminary evaluation of a thermal-based approach that relies on temperature and perfusion measurements. Two simple thermal models are used to contextualize results obtained from this technique. Results reveal that this thermal-based method serves as a valid indicator of endothelial assessment while at the same time reducing some of the mitigating factors of existing approaches to identifying endothelial dysfunction. More testing must be performed in order to optimize this thermal-based approach.
Description
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.
Includes bibliographical references (leaves 51-54).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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