Functional Surfactants for Molecular Fishing, Capsule Creation, and Single-Cell Gene Expression
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40820_2021_Article_663.pdf
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2.88 MB
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Author(s)
Chowdhury, Mohammad Suman
Zhang, Xingcai
Amini, Leila
Dey, Pradip
Singh, Abhishek Kumar
Faghani, Abbas
Schmueck-Henneresse, Michael
Haag, Rainer
Date Issued
January 2021
Journal
Nano-Micro Letters
Publisher
Springer Science and Business Media LLC
Citation
Nano-Micro Letters. 2021 Jun 19;13(1):147
Version
Final published version
Abstract
AbstractCreating a single surfactant that is open to manipulation, while maintaining its surface activity, robustness, and compatibility, to expand the landscape of surfactant-dependent assays is extremely challenging. We report an oxidation-responsive precursor with thioethers and multiple 1,2-diols for creating a variety of functional surfactants from one parent surfactant. Using these multifunctional surfactants, we stabilize microfluidics-generated aqueous droplets. The droplets encapsulate different components and immerse in a bioinert oil with distinct interfaces where an azide-bearing surfactant allow fishing of biomolecules from the droplets, aldehyde-bearing surfactant allow fabrication of microcapsules, and hydroxyl-bearing surfactants, with/without oxidized thioethers, allow monitoring of single-cell gene expression. Creating multifunctional surfactants poses opportunities for broad applications, including adsorption, bioanalytics, catalysis, formulations, coatings, and programmable subset of emulsions.
MIT Department
Massachusetts Institute of Technology. School of Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1007/s40820-021-00663-x
