Microfluidic models for adoptive cell-mediated cancer immunotherapies
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nihms-786883.pdf
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849.94 KB
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Checksum (MD5)
19207197b4db540d16e72495b9ad8935
Author(s)
Adriani, Giulia
Pavesi, Andrea
Tan, Anthony T.
Bertoletti, Antonio
Thiery, Jean Paul
Kamm, Roger Dale
Date Issued
May 2016
Journal
Drug Discovery Today
Publisher
Elsevier
Citation
Adriani, Giulia et al. “Microfluidic Models for Adoptive Cell-Mediated Cancer Immunotherapies.” Drug Discovery Today 21, 9 (September 2016): 1472–1478 © 2016 Elsevier Ltd
Version
Author's final manuscript
Abstract
Current adoptive T cell therapies have shown promising results in clinical trials but need further development as an effective cancer treatment. Here, we discuss how 3D microfluidic tumour models mimicking the tumour microenvironment could help in testing T cell immunotherapies by assessing engineered T cells and identifying combinatorial therapy to improve therapeutic efficacy. We propose that 3D microfluidic systems can be used to screen different patient-specific treatments, thereby reducing the burden of in vivo testing and facilitating the rapid translation of successful T cell cancer immunotherapies to the clinic.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.DRUDIS.2016.05.006
