How Does Multistep Tumorigenesis Really Proceed?
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nihms639736.pdf
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381.38 KB
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Author(s)
Chaffer, Christine L.
Weinberg, Robert A
Date Issued
January 2015
Journal
Cancer Discovery
Publisher
American Association for Cancer Research (AACR)
Citation
Chaffer, Christine L., and Robert A. Weinberg. “How Does Multistep Tumorigenesis Really Proceed?” Cancer Discovery 5, no. 1 (January 2015): 22–24.
Version
Author's final manuscript
Abstract
Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter the stem cell state. This model contrasts with the notion that cancer stem cells are the direct products of neoplastically transformed normal tissue stem cells.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1158/2159-8290.CD-14-0788
