Conservation and divergence in the transcriptional programs of the human and mouse immune systems
Name
Shay-2013-Conservation and divergence.pdf
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2.38 MB
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Adobe PDF
Checksum (MD5)
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Author(s)
Shay, Tal
Jojic, Vladimir
Zuk, Or
Rothamel, Katherine
Puyraimond-Zemmour, David
Feng, Ting
Wakamatsu, Ei
Benoist, Christophe
Koller, Daphne
Regev, Aviv
Date Issued
February 2013
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Shay, T., V. Jojic, O. Zuk, K. Rothamel, D. Puyraimond-Zemmour, T. Feng, E. Wakamatsu, C. Benoist, D. Koller, and A. Regev. “Conservation and divergence in the transcriptional programs of the human and mouse immune systems.” Proceedings of the National Academy of Sciences 110, no. 8 (February 19, 2013): 2946-2951.
Version
Final published version
Abstract
Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are conserved, particularly for lineage-specific genes. However, several hundred genes show clearly divergent expression across the examined cell lineages, and among them, 169 genes did so even with highly stringent criteria. Finally, regulatory mechanisms—reflected by regulators’ differential expression or enriched cis-elements—are conserved between the species but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1222738110
