Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life
Name
nihms-979917.pdf
Description
Accepted version
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597.32 KB
Format
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Author(s)
Yassour, Moran
Jason, Eeva
Hogstrom, Larson J.
Arthur, Timothy D.
Tripathi, Surya
Siljander, Heli
Selvenius, Jenni
Oikarinen, Sami
Hyöty, Heikki
Virtanen, Suvi M.
Date Issued
July 2018
Journal
Cell Host & Microbe
Publisher
Elsevier BV
Citation
Yassour, Moran et al. "Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life." Cell Host & Microbe 24, 1 (July 2018): P146-154.e4 © 2018 Elsevier Inc
Version
Author's final manuscript
Abstract
Bacterial community acquisition in the infant gut impacts immune education and disease susceptibility. We compared bacterial strains across and within families in a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child's life. We identified mother-to-child bacterial transmission events and describe the incidence of family-specific antibiotic resistance genes. We observed two inheritance patterns across multiple species, where often the mother's dominant strain is transmitted to the child, but occasionally her secondary strains colonize the infant gut. In families where the secondary strain of B. uniformis was inherited, a starch utilization gene cluster that was absent in the mother's dominant strain was identified in the child, suggesting the selective advantage of a mother's secondary strain in the infant gut. Our findings reveal mother-to-child bacterial transmission events at high resolution and give insights into early colonization of the infant gut. Using longitudinal metagenomic sequencing from 44 mother/child pairs, Yassour et al. characterized mother-to-child strain transmission patterns. While mothers' dominant strains were often inherited, nondominant secondary strain transmissions were also observed. Microbial functional analysis reveals that inherited maternal secondary strains may have a selective advantage to colonize infant guts.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.chom.2018.06.007
