NAD+ and sirtuins in aging and disease
Name
Guarente_NAD and sirtuins.pdf
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854.92 KB
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Checksum (MD5)
55a60577752e813f55fd532a7b34a6dc
Author(s)
Imai, Shin-ichiro
Guarente, Leonard Pershing
Date Issued
August 2014
Journal
Trends in Cell Biology
Publisher
Elsevier
Citation
Imai, Shin-ichiro, and Leonard Guarente. “NAD+ and Sirtuins in Aging and Disease.” Trends in Cell Biology 24.8 (2014): 464–471.
Version
Author's final manuscript
Abstract
Nicotinamide adenine dinucleotide (NAD[superscript +]) is a classical coenzyme mediating many redox reactions. NAD[superscript +] also plays an important role in the regulation of NAD[superscript +]-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD[superscript +] biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD[superscript +] levels decline during the aging process and may be an Achilles’ heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD[superscript +] by supplementing NAD[superscript +] intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD[superscript +] intermediate supplementation may be an effective antiaging intervention, providing hope to aging societies worldwide.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.tcb.2014.04.002
