The SirT3 Divining Rod Points to Oxidative Stress
Name
Guarente_The SirT3.pdf
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559.33 KB
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Adobe PDF
Checksum (MD5)
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Author(s)
Bell, Eric L.
Guarente, Leonard Pershing
Date Issued
June 2011
Journal
Molecular Cell
Publisher
Elsevier
Citation
Bell, Eric L., and Leonard Guarente. “The SirT3 Divining Rod Points to Oxidative Stress.” Molecular Cell 42, no. 5 (June 2011): 561-568. Copyright © 2011 Elsevier Inc.
Version
Final published version
Abstract
Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the nucleus. More recent findings highlight SirT3 as a mitochondrial sirtuin that regulates metabolism and oxidative stress. This review focuses on new data linking SirT3 to management of reactive oxygen species from mitochondria, which may have profound implications for aging and late-onset diseases.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology)
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.molcel.2011.05.008
