Flow of Cortical Activity Underlying a Tactile Decision in Mice
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Feng_Flow of cortical.pdf
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Author(s)
Guo, Zengcai V.
Li, Nuo
Huber, Daniel
Ophir, Eran
Gutnisky, Diego
Feng, Guoping
Svoboda, Karel
Ting, Jonathan Thomas
Date Issued
December 2013
Journal
Neuron
Publisher
Elsevier
Citation
Guo, Zengcai V., Nuo Li, Daniel Huber, Eran Ophir, Diego Gutnisky, Jonathan T. Ting, Guoping Feng, and Karel Svoboda. “Flow of Cortical Activity Underlying a Tactile Decision in Mice.” Neuron 81, no. 1 (January 2014): 179–194.
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Author's final manuscript
Abstract
Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile “sensation” and “action” (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms), we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2013.10.020
