Implantable system for chronotherapy
Name
sciadv.abj4624.pdf
Description
Published version
Size
2.01 MB
Format
Adobe PDF
Checksum (MD5)
e32794616b30d7c448c289f4a1075ea9
Author(s)
Lee, Seung Ho
Wan, Qianqian
Wentworth, Adam
Ballinger, Ian
Ishida, Keiko
Collins, Joy E.
Tamang, Siddartha
Huang, Hen-Wei
Li, Canchen
Hess, Kaitlyn
Date Issued
November 26, 2021
Journal
Science Advances
Publisher
American Association for the Advancement of Science
Citation
Seung Ho Lee et al. ,Implantable system for chronotherapy.Sci. Adv.7,eabj4624(2021).
Version
Final published version
Abstract
Diurnal variation in enzymes, hormones, and other biological mediators has long been recognized in mammalian physiology. Developments in pharmacobiology over the past few decades have shown that timing drug delivery can enhance drug efficacy. Here, we report the development of a battery-free, refillable, subcutaneous, and trocar-compatible implantable system that facilitates chronotherapy by enabling tight control over the timing of drug administration in response to external mechanical actuation. The external wearable system is coupled to a mobile app to facilitate control over dosing time. Using this system, we show the efficacy of bromocriptine on glycemic control in a diabetic rat model. We also demonstrate that antihypertensives can be delivered through this device, which could have clinical applications given the recognized diurnal variation of hypertension-related complications. We anticipate that implants capable of chronotherapy will have a substantial impact on our capacity to enhance treatment effectiveness for a broad range of chronic conditions.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1126/sciadv.abj4624
