Observations in the Synthesis of the Core of the Antitumor Illudins via an Enyne Ring Closing Metathesis Cascade
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983.51 KB
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Author(s)
Movassaghi, Mohammad
Piizzi, Grazia
Siegel, Dustin Scott
Piersanti, Giovanni
Date Issued
July 2009
Journal
Tetrahedron Letters
Publisher
Elsevier
Citation
Movassaghi, Mohammad et al. “Observations in the Synthesis of the Core of the Antitumor Illudins via an Enyne Ring Closing Metathesis Cascade.” Tetrahedron Letters 50.39 (2009): 5489–5492.
Version
Author's final manuscript
Abstract
Observations concerning the synthesis of the core spirocyclic AB-ring system of illudins using an enyne ring closing metathesis (EYRCM) cascade are discussed. Substituent effects, in addition to optimization of the reaction conditions and the olefin tether for the key EYRCM reaction, are examined.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.tetlet.2009.07.102
