Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG
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Leibfarth-2015-Scalable synthesis o.pdf
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1.05 MB
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Author(s)
Leibfarth, Frank A.
Johnson, Jeremiah A.
Jamison, Timothy F.
Date Issued
August 2015
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Leibfarth, Frank A., Jeremiah A. Johnson, and Timothy F. Jamison. “Scalable Synthesis of Sequence-Defined, Unimolecular Macromolecules by Flow-IEG.” Proc Natl Acad Sci USA 112, no. 34 (August 12, 2015): 10617–10622.
Version
Final published version
Abstract
We report a semiautomated synthesis of sequence and architecturally defined, unimolecular macromolecules through a marriage of multistep flow synthesis and iterative exponential growth (Flow-IEG). The Flow-IEG system performs three reactions and an in-line purification in a total residence time of under 10 min, effectively doubling the molecular weight of an oligomeric species in an uninterrupted reaction sequence. Further iterations using the Flow-IEG system enable an exponential increase in molecular weight. Incorporating a variety of monomer structures and branching units provides control over polymer sequence and architecture. The synthesis of a uniform macromolecule with a molecular weight of 4,023 g/mol is demonstrated. The user-friendly nature, scalability, and modularity of Flow-IEG provide a general strategy for the automated synthesis of sequence-defined, unimolecular macromolecules. Flow-IEG is thus an enabling tool for theory validation, structure–property studies, and advanced applications in biotechnology and materials science.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1508599112
