Networks of bZIP Protein-Protein Interactions Diversified Over a Billion Years of Evolution
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Reinke_Science_2013_authorversion.pdf
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Author(s)
Reinke, Aaron W.
Baek, Jiyeon
Ashenberg, Orr
Keating, Amy E.
Date Issued
May 2013
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Reinke, A. W., J. Baek, O. Ashenberg, and A. E. Keating. “Networks of bZIP Protein-Protein Interactions Diversified Over a Billion Years of Evolution.” Science 340, no. 6133 (May 10, 2013): 730–734.
Version
Author's final manuscript
Abstract
Differences in biomolecular sequence and function underlie dramatic ranges of appearance and behavior among species. We studied the basic region-leucine zipper (bZIP) transcription factors and quantified bZIP dimerization networks for five metazoan and two single-cell species, measuring interactions in vitro for 2891 protein pairs. Metazoans have a higher proportion of heteromeric bZIP interactions and more network complexity than the single-cell species. The metazoan bZIP interactomes have broadly similar structures, but there has been extensive rewiring of connections compared to the last common ancestor, and each species network is highly distinct. Many metazoan bZIP orthologs and paralogs have strikingly different interaction specificities, and some differences arise from minor sequence changes. Our data show that a shifting landscape of biochemical functions related to signaling and gene expression contributes to species diversity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.1233465
