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Rethinking Single Neuron Electrical Compartmentalization: Dendritic Contributions to Network Computation In Vivo
Name
1-s2.0-S0306452221002852-main.pdf
Description
Published version
Size
1.77 MB
Format
Adobe PDF
Checksum (MD5)
e89f233c3d44867fa596d2f7a7f53481
Author(s)
Francioni, Valerio
Harnett, Mark T
Date Issued
2021
Journal
Neuroscience
Publisher
Elsevier BV
Citation
Francioni, Valerio and Harnett, Mark T. 2021. "Rethinking Single Neuron Electrical Compartmentalization: Dendritic Contributions to Network Computation In Vivo." Neuroscience.
Version
Final published version
Abstract
Decades of experimental and theoretical work support a now well-established theory that active dendritic processing contributes to the computational power of individual neurons. This theory is based on the high degree of electrical compartmentalization observed in the dendrites of single neurons in ex vivo preparations. Compartmentalization allows dendrites to conduct semi-independent operations on their inputs before final integration and output at the axon, producing a "network-in-a-neuron." However, recent in vivo functional imaging experiments in mouse cortex have reported surprisingly little evidence for strong dendritic compartmentalization. In this review, we contextualize these new findings and discuss their impact on the future of the field. Specifically, we consider how highly coordinated, and thus less compartmentalized, activity in soma and dendrites can contribute to cortical computations including nonlinear mixed selectivity, prediction/expectation, multiplexing, and credit assignment.
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/J.NEUROSCIENCE.2021.05.038
