Oral delivery of biologics using drug-device combinations
Name
nihms894914.pdf
Description
Accepted version
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181.48 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Caffarel Salvador, Ester
Abramson, Alex
Langer, Robert S
Traverso, Giovanni
Date Issued
August 2017
Journal
Current Opinion in Pharmacology
Publisher
Elsevier BV
Citation
Caffarel-Salvador, Ester et al., "Oral delivery of biologics using drug-device combinations." Current Opinion in Pharmacology 36 (October 2017): 8-13 doi. 10.1016/j.coph.2017.07.003 ©2017 Authors
Version
Author's final manuscript
Abstract
Orally administered devices could enable the systemic uptake of biologic therapeutics by engineering around the physiological barriers present in the gastrointestinal (GI) tract. Such devices aim to shield cargo from degradative enzymes and increase the diffusion rate of medication through the GI mucosa. In order to achieve clinical relevance, these designs must significantly increase systemic drug bioavailability, deliver a clinically relevant dose and remain safe when taken frequently. Such an achievement stands to reduce our dependence on needle injections, potentially increasing patient adherence and reducing needle-associated complications. Here we discuss the physical and chemical constraints imposed by the GI organs and use these to develop a set of boundary conditions on oral device designs for the delivery of macromolecules. We critically examine how device size affects the rate of intestinal obstruction and hinders the loading capacity of poorly soluble protein drugs. We then discuss how current orally administered devices could solve the problem of tissue permeation and conclude that these physical methods stand to provide an efficacious set of alternatives to the classic hypodermic needle. ©2017 Elsevier Ltd
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.COPH.2017.07.003
