Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid–Glucose Complexation
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Author(s)
Dong, Yizhou
Xue, Kun
Weir, Gordon C.
Wang, Weiheng
Veiseh, Omid
Appel, Eric
Webber, Matthew
Tang, Benjamin C.
Yang, Xiwen
Langer, Robert S
Date Issued
July 2016
Journal
Langmuir
Publisher
American Chemical Society (ACS)
Citation
Dong, Yizhou et al. “Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid–Glucose Complexation.” Langmuir 32, 34 (August 2016): 8743–8747 © 2016 American Chemical Society
Version
Author's final manuscript
Abstract
Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid–glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10–60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/acs.langmuir.5b04755
