Biomaterials for Personalized Cell Therapy
Name
adma201902005_edited_190823_.pdf
Description
Submitted version
Size
1.32 MB
Format
Adobe PDF
Checksum (MD5)
f668f10b3d91857e6e9860d20c72fc74
Author(s)
Facklam, Amanda L.
Volpatti, Lisa R
Anderson, Daniel Griffith
Date Issued
September 2019
Journal
Advanced Materials
Publisher
Wiley
Citation
Facklam, Amanda L. et al. "Biomaterials for Personalized Cell Therapy." Advanced Materials 32, 13 (September 2019): 1902005. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Version
Original manuscript
Abstract
Cell therapy has already had an important impact on healthcare and provided new treatments for previously intractable diseases. Notable examples include mesenchymal stem cells for tissue regeneration, islet transplantation for diabetes treatment, and T cell delivery for cancer immunotherapy. Biomaterials have the potential to extend the therapeutic impact of cell therapies by serving as carriers that provide 3D organization and support cell viability and function. With the growing emphasis on personalized medicine, cell therapies hold great potential for their ability to sense and respond to the biology of an individual patient. These therapies can be further personalized through the use of patient-specific cells or with precision biomaterials to guide cellular activity in response to the needs of each patient. Here, the role of biomaterials for applications in tissue regeneration, therapeutic protein delivery, and cancer immunotherapy is reviewed, with a focus on progress in engineering material properties and functionalities for personalized cell therapies.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adma.201902005
