Dissecting the spatial structure of overlapping transcription in budding yeast
Name
631176066-MIT.pdf
Description
Full printable version
Size
9.94 MB
Format
Adobe PDF
Checksum (MD5)
ee647f141449a5d8a3f22316f34188ba
Author(s)
Danford, Timothy W. (Timothy William), 1979-
Advisor(s)
David K. Gifford.
Date Issued
2010
Publisher
Massachusetts Institute of Technology
Abstract
This thesis presents a computational and algorithmic method for the analysis of high-resolution transcription data in the budding yeast Saccharomyces cerevisiae. We begin by describing a computational system for storing and retrieving spatially-mapped genomic data. This system forms the infrastructure for a novel algorithmic approach to detect and recover instances of same-strand overlapping transcripts in high resolution expression experiments. We then apply these algorithms to a set of transcription experiments in budding yeast, Saccharomyces cerevisiae, in order to identify potential sites of same-strand overlapping transcripts that may be involved in novel forms of transcriptional regulation.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 95-102).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
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