Thymic Selection of T-Cell Receptors as an Extreme Value Problem
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Author(s)
Kardar, Mehran
Chakraborty, Arup K.
Shaknovich, Eugene I.
Kosmrlj, Andrej
Date Issued
August 2009
Journal
Physical Review Letters
Publisher
American Physical Society
Citation
Kosmrlj, Andrej et al. “Thymic Selection of T-Cell Receptors as an Extreme Value Problem.” Physical Review Letters 103.6 (2009): 068103. © 2009 The American Physical Society.
Version
Final published version
Abstract
T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Physics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
http://dx.doi.org/10.1103/PhysRevLett.103.068103
