Synthesis of the EFG Framework of Tamulamides A and B

Kelley, Elizabeth H; Jamison, Timothy F

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Synthesis of the EFG Framework of Tamulamides A and B

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Author(s)

Kelley, Elizabeth H

•

Jamison, Timothy F

Journal

Organic Letters

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American Chemical Society (ACS)

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Author's final manuscript

Abstract

© 2019 American Chemical Society. Synthesis of the fused polycyclic ether motif comprising the EFG rings of the marine ladder polyethers tamulamides A and B has been achieved via two different etherification strategies. Ultimately, a reductive etherification approach proved most successful due to tolerance of the G ring substitution and provided the EFG 6,7,6 ring system in 58% yield.

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https://hdl.handle.net/1721.1/132391

DOI of Published Version

10.1021/ACS.ORGLETT.9B03015