Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer
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Langer_Therapeutic effect.pdf
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Author(s)
Urbanska, Aleksandra M.
Guajardo, Gonzalo
Karagiannis, Emmanouil
Anderson, Daniel Griffith
Langer, Robert S
Date Issued
April 2012
Journal
Biomaterials
Publisher
Elsevier
Citation
Urbanska, Aleksandra M., Emmanouil D. Karagiannis, Gonzalo Guajardo, Robert S. Langer, and Daniel G. Anderson. “Therapeutic Effect of Orally Administered Microencapsulated Oxaliplatin for Colorectal Cancer.” Biomaterials 33, no. 18 (June 2012): 4752–4761.
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Author's final manuscript
Abstract
Colorectal cancer is a significant source of morbidity and mortality in the United States and other Western countries. Oral delivery of therapeutics remains the most patient accepted form of medication. The development of an oral delivery formulation for local delivery of chemotherapeutics in the gastrointestinal tract can potentially alleviate the adverse side effects including systemic cytotoxicity, as well as focus therapy to the lesions. Here we develop an oral formulation of the chemotherapeutic drug oxaliplatin for the treatment of colorectal cancer. Oxaliplatin was encapsulated in pH sensitive, mucoadhesive chitosan-coated alginate microspheres. The microparticles were formulated to release the chemotherapeutics after passing through the acidic gastric environment thus targeting the intestinal tract. In vivo, these particles substantially reduced the tumor burden in an orthotopic mouse model of colorectal cancer, and reduced mortality.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Media Laboratory
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1016/j.biomaterials.2012.03.023
