Designer peptides to understand the mineralization of calcium salts
Name
MEBCS006.pdf
Size
2.97 MB
Format
Adobe PDF
Checksum (MD5)
3b660cd5397b68f478781823b6850ded
Author(s)
Ajikumar, Parayil Kumaran
Lakshminarayanan, Rajamani
Valiyaveettil, Suresh
Kini, R. Manjunatha
Date Issued
January 2003
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Recently, we reported the extraction, purification and amino acid sequence of ansocalcin, the major goose eggshell matrix protein. In vitro studies showed that ansocalcin induces spherical calcite crystal aggregates. We designed two peptides using the unique features of the sequence of ansocalcin and the role of these peptides in CaCO₃ crystallization was investigated. The peptides showed similar activities as compared to ansocalcin, but at a higher concentration. The full characterization of the peptides and a rational for the observed morphology for the calcite crystals are discussed in detail.
Subjects
biomineralization
calcium carbonate
crystallization
oligopeptides
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