The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity
Name
nihms-1718956.pdf
Description
Accepted version
Size
1.87 MB
Format
Adobe PDF
Checksum (MD5)
1671918f3fcf0025f8c07d884584bf61
Author(s)
Finnie, Peter SB
Komorowski, Robert W
Bear, Mark F
Date Issued
2021
Journal
Current Biology
Publisher
Elsevier BV
Citation
Finnie, Peter SB, Komorowski, Robert W and Bear, Mark F. 2021. "The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity." Current Biology, 31 (18).
Version
Author's final manuscript
Abstract
The hippocampus and neocortex are theorized to be crucial partners in the formation of long-term memories. Here, we assess hippocampal involvement in two related forms of experience-dependent plasticity in the primary visual cortex (V1) of mice. Like control animals, those with hippocampal lesions exhibit potentiation of visually evoked potentials after passive daily exposure to a phase-reversing oriented grating stimulus, which is accompanied by long-term habituation of a reflexive behavioral response. Thus, low-level recognition memory is formed independently of the hippocampus. However, response potentiation resulting from daily exposure to a fixed sequence of four oriented gratings is severely impaired in mice with hippocampal damage. A feature of sequence plasticity in V1 of controls, which is absent in lesioned mice, is the generation of predictive responses to an anticipated stimulus element when it is withheld or delayed. Thus, the hippocampus is involved in encoding temporally structured experience, even within the primary sensory cortex.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.CUB.2021.06.079
