Synthetic and living micropropellers for convection-enhanced nanoparticle transport
Name
eaav4803.full.pdf
Description
Published version
Size
827.42 KB
Format
Adobe PDF
Checksum (MD5)
417f2e6c45d34ef28d1283b33cdcd74d
Author(s)
Schuerle, S
Soleimany, Ava
Yeh, Tiffany
Anand, G. M.
Häberli, M
Fleming, Heather
Mirkhani, N
Qiu, F
Hauert, S
Wang, X
Date Issued
April 2019
Journal
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Schuerle, S. et al. "Synthetic and living micropropellers for convection-enhanced nanoparticle transport." Science Advances 5, 4 (April 2019): eaav4803 © 2019 The Authors
Version
Final published version
Abstract
Nanoparticles (NPs) have emerged as an advantageous drug delivery platform for the treatment of various ailments including cancer and cardiovascular and inflammatory diseases. However, their efficacy in shuttling materials to diseased tissue is hampered by a number of physiological barriers. One hurdle is transport out of the blood vessels, compounded by difficulties in subsequent penetration into the target tissue. Here, we report the use of two distinct micropropellers powered by rotating magnetic fields to increase diffusion-limited NP transport by enhancing local fluid convection. In the first approach, we used a single synthetic magnetic microrobot called an artificial bacterial flagellum(ABF), and in the second approach,we used swarms of magnetotactic bacteria (MTB) to create a directable "living ferrofluid" by exploiting ferrohydrodynamics. Both approaches enhance NP transport in a microfluidicmodel of blood extravasation and tissue penetration that consists of microchannels bordered by a collagen matrix.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/SCIADV.AAV4803
