c-Myc regulates transcriptional pause release
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Burge_c-Myc regulates.pdf
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1.78 MB
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Author(s)
Rahl, Peter B.
Lin, Charles Y.
Flynn, Ryan A.
McCuine, Scott
Sharp, Phillip A.
Young, Richard A.
White, Amy C.
Burge, Christopher B
Date Issued
April 2010
Journal
Cell
Publisher
Elsevier
Citation
Rahl, Peter B. et al. “c-Myc Regulates Transcriptional Pause Release.” Cell 141.3 (2010): 432–445.
Version
Author's final manuscript
Abstract
Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA-binding transcription factors is well recognized as a key regulatory step in gene expression. We report here that promoter-proximal pausing is a general feature of transcription by Pol II in mammalian cells and thus an additional step where regulation of gene expression occurs. This suggests that some transcription factors recruit the transcription apparatus to promoters, whereas others effect promoter-proximal pause release. Indeed, we find that the transcription factor c-Myc, a key regulator of cellular proliferation, plays a major role in Pol II pause release rather than Pol II recruitment at its target genes. We discuss the implications of these results for the role of c-Myc amplification in human cancer.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.cell.2010.03.030
