Nutrient-sensing mechanisms and pathways
Name
nihms-657562.pdf
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1.42 MB
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Adobe PDF
Checksum (MD5)
abc5404b7965129b1e6d7a445671ec90
Author(s)
Efeyan, Alejo
Comb, William C.
Sabatini, David
Date Issued
January 2015
Journal
Nature
Publisher
Nature Publishing Group
Citation
Efeyan, Alejo, William C. Comb, and David M. Sabatini. “Nutrient-Sensing Mechanisms and Pathways.” Nature 517, no. 7534 (January 14, 2015): 302–10.
Version
Author's final manuscript
Abstract
The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/nature14190
