Determinants of nutrient limitation in cancer
Name
nihms-1531336.pdf
Description
Accepted version
Size
1 MB
Format
Adobe PDF
Checksum (MD5)
38358270e1f2bc453ec9f83a30c2c003
Author(s)
Sullivan, Mark Robert
Vander Heiden, Matthew G.
Date Issued
May 2019
Journal
Critical Reviews in Biochemistry and Molecular Biology
Publisher
Informa UK Limited
Citation
Sullivan, Mark R. and Matthew G. Vander Heiden. "Determinants of nutrient limitation in cancer." Critical Reviews in Biochemistry and Molecular Biology 54, 3 (May 2019): 193-207 © 2019 Informa UK Limited
Version
Author's final manuscript
Abstract
Proliferation requires that cells accumulate sufficient biomass to grow and divide. Cancer cells within tumors must acquire a variety of nutrients, and tumor growth slows or stops if necessary metabolites are not obtained in sufficient quantities. Importantly, the metabolic demands of cancer cells can be different from those of untransformed cells, and nutrient accessibility in tumors is different than in many normal tissues. Thus, cancer cell survival and proliferation may be limited by different metabolic factors than those that are necessary to maintain noncancerous cells. Understanding the variables that dictate which nutrients are critical to sustain tumor growth may identify vulnerabilities that could be used to treat cancer. This review examines the various cell-autonomous, local, and systemic factors that determine which nutrients are limiting for tumor growth.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1080/10409238.2019.1611733
