Targeting cancer metabolism: a therapeutic window opens
Name
Vander Heiden FINAL-1.pdf
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3.35 MB
Format
Adobe PDF
Checksum (MD5)
c67d6b641ad93959eb4e61b9f0166c96
Author(s)
Vander Heiden, Matthew G.
Date Issued
September 2011
Journal
Nature Reviews Drug Discovery
Publisher
Nature Publishing Group
Citation
Vander Heiden, Matthew G. “Targeting Cancer Metabolism: a Therapeutic Window Opens.” Nature Reviews Drug Discovery 10.9 (2011): 671–684.
Version
Author's final manuscript
Abstract
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic enzymes for cancer therapy, but they have also raised concerns that these therapies would have unacceptable effects on normal cells. However, some of the first cancer therapies that were developed target the specific metabolic needs of cancer cells and remain effective agents in the clinic today. Research into how changes in cell metabolism promote tumour growth has accelerated in recent years. This has refocused efforts to target metabolic dependencies of cancer cells as a selective anticancer strategy.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nrd3504
