Hippocampal Replay of Extended Experience
Name
Davidson-2009-Hippocampal Replay o.pdf
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1.1 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Davidson, Thomas J.
Kloosterman, Fabian
Wilson, Matthew A.
Date Issued
August 2009
Journal
Neuron
Publisher
Elsevier B.V.
Citation
Davidson, Thomas J., Fabian Kloosterman, and Matthew A. Wilson. “Hippocampal Replay of Extended Experience.” Neuron 63, no. 4 (August 2009): 497–507. © 2009 Elsevier Inc.
Version
Final published version
Abstract
During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences corresponding to recent spatial experience. Such “replay” co-occurs with ripple events: short-lasting (∼50–120 ms), high-frequency (∼200 Hz) oscillations that are associated with increased hippocampal-cortical communication. In previous studies, rats exploring small environments showed replay anchored to the rat's current location and compressed in time into a single ripple event. Here, we show, using a neural decoding approach, that firing sequences corresponding to long runs through a large environment are replayed with high fidelity and that such replay can begin at remote locations on the track. Extended replay proceeds at a characteristic virtual speed of ∼8 m/s and remains coherent across trains of ripple events. These results suggest that extended replay is composed of chains of shorter subsequences, which may reflect a strategy for the storage and flexible expression of memories of prolonged experience.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.neuron.2009.07.027
