Planarian regeneration involves distinct stem cell responses to wounds and tissue absence
Name
Wenemoser-2010-Planarian regenerati.pdf
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3.49 MB
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Adobe PDF
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4e35d03fcb25cafa2a1f65596fa33c12
Author(s)
Wenemoser, Danielle
Reddien, Peter
Date Issued
June 2010
Journal
Developmental Biology
Publisher
Elsevier
Citation
Wenemoser, Danielle, and Peter W. Reddien. “Planarian Regeneration Involves Distinct Stem Cell Responses to Wounds and Tissue Absence.” Developmental Biology 344, no. 2 (August 2010): 979–991. © 2010 Elsevier Inc.
Version
Final published version
Abstract
Regeneration requires signaling from a wound site for detection of the wound and a mechanism that determines the nature of the injury to specify the appropriate regenerative response. Wound signals and tissue responses to wounds that elicit regeneration remain poorly understood. Planarians are able to regenerate from essentially any type of injury and present a novel system for the study of wound responses in regeneration initiation. Newly developed molecular and cellular tools now enable study of regeneration initiation using the planarian Schmidtea mediterranea. Planarian regeneration requires adult stem cells called neoblasts and amputation triggers two peaks in neoblast mitoses early in regeneration. We demonstrate that the first mitotic peak is a body-wide response to any injury and that a second, local, neoblast response is induced only when injury results in missing tissue. This second response was characterized by recruitment of neoblasts to wounds, even in areas that lack neoblasts in the intact animal. Subsequently, these neoblasts were induced to divide and differentiate near the wound, leading to formation of new tissue. We conclude that there exist two functionally distinct signaling phases of the stem cell wound response that distinguish between simple injury and situations that require the regeneration of missing tissue.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.ydbio.2010.06.017
