Tomographic phase microscopy: principles and applications in bioimaging [Invited]
Name
nihms925582.pdf
Size
1.15 MB
Format
Adobe PDF
Checksum (MD5)
c4c8c562e710e492949ec37e7fac8941
Author(s)
Jin, Di
Zhou, Renjie
Yaqoob, Zahid
So, Peter T. C.
Date Issued
April 2017
Journal
Journal of the Optical Society of America B
Publisher
The Optical Society
Citation
Jin, Di, Renjie Zhou, Zahid Yaqoob, and Peter T. C. So. “Tomographic Phase Microscopy: Principles and Applications in Bioimaging [Invited].” Journal of the Optical Society of America B 34, no. 5 (April 4, 2017): B64.
Version
Author's final manuscript
Abstract
Tomographic phase microscopy (TPM) is an emerging optical microscopic technique for bioimaging. TPM uses digital holographic measurements of complex scattered fields to reconstruct three-dimensional refractive index (RI) maps of cells with diffraction-limited resolution by solving inverse scattering problems. In this paper, we review the developments of TPM from the fundamental physics to its applications in bioimaging. We first provide a comprehensive description of the tomographic reconstruction physicalmodels used in TPM. The RI map reconstruction algorithms and various regularization methods are discussed. Selected TPM applications for cellular imaging, particularly in hematology, are reviewed. Finally, we examine the limitations of current TPM systems, propose future solutions, and envision promising directions in biomedical research.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Spectroscopy Laboratory
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1364/JOSAB.34.000B64
