Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug
Name
831413038-MIT.pdf
Description
Full printable version
Size
5.64 MB
Format
Adobe PDF
Checksum (MD5)
0bd126708a7036580aa71da88256fce5
Author(s)
Li, Meiyi, S.M. Massachusetts Institute of Technology
Advisor(s)
Stephen J. Lippard.
Date Issued
2012
Publisher
Massachusetts Institute of Technology
Abstract
Nucleotide excision repair, a DNA repair mechanism, is the major repair pathway responsible for removal of platinum-based anticancer drugs. In this study, 146 bp duplexes were prepared containing either a site-specific cisdiammineplatinum( Il)-DNA intrastrand d(GpG) cross-link or a cisdiamminephenanthridinechloroplatinum( Il)-DNA dG adduct. Comparison of the repair efficiencies of the two adducts reveals that the diamminephenanthridinechloroplatinum(lI)-DNA dG lesion eludes the nucleotide excision repair pathway better than diammineplatinum(lI)-DNA intrastrand d(GpG) cross-link. A factor that may be relevant to the difference is the influence of platination on DNA-mediated charge transfer. Atomic force microscopy is a method by which we can explore the possibility that phenanthriplatin influences charge transfer properties of DNA. Long DNA duplexes site-specifically modified with cisplatin or phenthanriplatin were prepared for AFM studies.
Description
Thesis (S.M. in Inorganic chemistry)--Massachusetts Institute of Technology, Dept. of Chemistry, 2012.
Cataloged from PDF version of thesis. Vita.
Includes bibliographical references (p. 38-40).
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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