Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study
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nihms352344.pdf
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693.56 KB
Format
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Checksum (MD5)
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Author(s)
Rosen, Allyson C.
Sugiura, Lisa
Kramer, Joel H.
Whitfield-Gabrieli, Susan
Gabrieli, John D. E.
Date Issued
2011
Journal
Journal of Alzheimer's Disease
Publisher
IOS Press
Citation
C, Rosen Allyson, et al. “Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study.” Journal of Alzheimer's Disease, no. s3, 2011, pp. 349–357.
Version
Author's final manuscript
Abstract
A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3233/JAD-2011-0009
