Deregulation of the G1/S-phase transition is the proximal cause of mortality in old yeast mother cells
Name
Genes Dev.-2018-Neurohr-1075-84.pdf
Description
Published version
Size
2.49 MB
Format
Adobe PDF
Checksum (MD5)
9539c2fd5b1829be645a57f4f5307049
Author(s)
Neurohr, Gabriel
Terry, Rachel L.
Sandikci, Arzu
Zou, Ke
Li, Hao
Amon, Angelika B
Date Issued
July 2018
Journal
Genes and Development
Publisher
Cold Spring Harbor Laboratory
Citation
Neurohr, Gabriel E. et al. "Deregulation of the G1/S-phase transition is the proximal cause of mortality in old yeast mother cells." Genes and Development 32, 15-16 (July 2018): 1075-1084 © 2018 Neurohr et al
Version
Final published version
Abstract
Budding yeast cells produce a finite number of daughter cells before they die. Why old yeast cells stop dividing and die is unclear. We found that age-induced accumulation of the G1/S-phase inhibitor Whi5 and defects in G1/S cyclin transcription cause cell cycle delays and genomic instability that result in cell death. We further identified extrachromosomal rDNA (ribosomal DNA) circles (ERCs) to cause the G1/S cyclin expression defect in old cells. Spontaneous segregation of Whi5 and ERCs into daughter cells rejuvenates old mothers, but daughters that inherit these aging factors die rapidly. Our results identify deregulation of the G1/S-phase transition as the proximal cause of age-induced proliferation decline and cell death in budding yeast.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
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DOI of Published Version
https://doi.org/10.1101/gad.312140.118
