Divergent Transcription: A Driving Force for New Gene Origination?
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Sharp_Divergent transcription.pdf
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Author(s)
Sharp, Phillip A.
Wu, Xuebing, Ph. D. Massachusetts Institute of Technology
Date Issued
November 2013
Journal
Cell
Publisher
Elsevier
Citation
Wu, Xuebing and Sharp, Phillip A. “Divergent Transcription: A Driving Force for New Gene Origination?” Cell 155, no. 5 (November 2013): 990–996 © 2013 Elsevier Inc
Version
Author's final manuscript
Abstract
The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.
MIT Department
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.cell.2013.10.048
