Replication–transcription conflicts in bacteria
Name
Grossman NRM for ILP April2012.pdf
Size
1.73 MB
Format
Adobe PDF
Checksum (MD5)
c72d1056b88af73bb6d8bc966011c358
Author(s)
Merrikh, Houra
Zhang, Yan
Wang, Jue D.
Grossman, Alan Davis
Date Issued
July 2012
Journal
Nature Reviews. Microbiology
Publisher
Nature Publishing Group
Citation
Merrikh, Houra et al. “Replication–transcription Conflicts in Bacteria.” Nature Reviews Microbiology (2012): p.449-458. CrossRef. Web.
Version
Author's final manuscript
Abstract
DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major advances have been made in understanding how cells avoid conflicts between replication and transcription and how such conflicts are resolved when they do occur. In this Review, we summarize these findings, which shed light on the significance of the problem and on how bacterial cells deal with unwanted encounters between the replication and transcription machineries.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nrmicro2800
