Sex differences in oncogenic mutational processes
Name
s41467-020-17359-2.pdf
Description
Published version
Size
2.19 MB
Format
Adobe PDF
Checksum (MD5)
33853fe3a0d2998795921aedb36e95b6
Author(s)
Li, Constance H.
Prokopec, Stephenie D.
Sun, Ren X.
Yousif, Fouad
Schmitz, Nathaniel
Boutros, Paul C.
Kellis, Manolis
PCAWG Consortium
Date Issued
August 2020
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Li, Constance H. et al. "Sex differences in oncogenic mutational processes." Nature Communications 11, 1 (August 2020): 4330 © 2020 The Author(s)
Version
Final published version
Abstract
Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41467-020-17359-2
