Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints
Name
Candela-2016-Alpha 5 Integrin Med.pdf
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24.27 MB
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Author(s)
Candela, Maria Elena
Gunawardena, Aruni T.
Zhang, Kairui
Cantley, Leslie
Yasuhara, Rika
Usami, Yu
Francois, Noelle
Iwamoto, Masahiro
van der Flier, Arjan
Zhang, Yejia
Date Issued
August 30, 2016
Journal
PLOS ONE
Citation
Candela, Maria Elena, Chao Wang, Aruni T. Gunawardena, Kairui Zhang, Leslie Cantley, Rika Yasuhara, Yu Usami, et al. “Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints.” Edited by Bart O. Williams. PLoS ONE 11, no. 6 (June 9, 2016): e0156783.
Version
Final published version
Abstract
Osteoarthritis (OA) is one of most common skeletal disorders and can affect synovial joints such as knee and ankle joints. α5 integrin, a major fibronectin receptor, is expressed in articular cartilage and has been demonstrated to play roles in synovial joint development and in the regulation of chondrocyte survival and matrix degradation in articular cartilage. We hypothesized that α5 integrin signaling is involved in pathogenesis of OA. To test this, we generated compound mice that conditionally ablate α5 integrin in the synovial joints using the Gdf5Cre system. The compound mice were born normally and had an overall appearance similar to the control mice. However, when the mutant mice received the OA surgery, they showed stronger resistance to osteoarthritic changes than the control. Specifically the mutant knee joints presented lower levels of cartilage matrix and structure loss and synovial changes and showed stronger biomechanical properties than the control knee joints. These findings indicate that α5 integrin may not be essential for synovial joint development but play a causative role in induction of osteoarthritic changes.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1371/journal.pone.0156783
