Eggshell Matrix Protein Mimetics: Elucidation of Molecular Mechanism of Goose Eggshell Calcification using Designed Peptides
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MEBCS007.pdf
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256.7 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Ajikumar, Parayil Kumaran
Lakshminarayanan, Rajamani
Valiyaveettil, Suresh
Kini, R. Manjunatha
Date Issued
January 2004
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Model peptides were designed, synthesized and conducted a detailed structure-property study to unravel the molecular mechanism of goose eggshell calcification. The peptides were designed based on the primary structural features of the eggshell matrix proteins ansocalcin and OC-17. In vitro CaCO₃ crystal growth experiments in presence of these peptides showed calcite crystal aggregation as observed in the case of the parent protein ansocalcin. The structure of these peptides in solution was established using intrinsic tryptophan fluorescence studies and quasi-elastic light scattering experiments. The structural features are correlated with observed results of the in vitro crystallization studies.
Subjects
ansocalcin
biomineralization
calcium carbonate
designed peptides
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