Palladium-Catalyzed Completely Linear-Selective Negishi Cross-Coupling of Allylzinc Halides with Aryl and Vinyl Electrophiles
Name
Buchwald_Palladium-catalyzed.pdf
Size
1.56 MB
Format
Adobe PDF
Checksum (MD5)
5a2ab89461a610a5a604ffac159b040d
Author(s)
Yang, Yang
Mustard, Thomas J. L.
Cheong, Paul Ha-Yeon
Buchwald, Stephen Leffler
Date Issued
November 2013
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Yang, Yang, Thomas J. L. Mustard, Paul Ha-Yeon Cheong, and Stephen L. Buchwald. “Palladium-Catalyzed Completely Linear-Selective Negishi Cross-Coupling of Allylzinc Halides with Aryl and Vinyl Electrophiles.” Angewandte Chemie International Edition 52, no. 52 (November 8, 2013): 14098–14102.
Version
Author's final manuscript
Abstract
Completely linear: The title reaction provides an effective means to access a wide range of prenylated arenes and “skipped dienes” in a completely linear-selective fashion, as demonstrated by a concise synthesis of the anti-HIV natural product siamenol. DFT calculations shed light on the origin of the excellent regioselectivity observed with the current Pd-based catalyst system.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/anie.201308585
