Regulation of gene expression and cell state in embryonic stem cells
Name
654127676-MIT.pdf
Description
Full printable version
Size
16.29 MB
Format
Adobe PDF
Checksum (MD5)
1844545132f09f70a810557c0f4427de
Author(s)
Newman, Jamie Jennifer
Advisor(s)
Richard A. Young.
Date Issued
2010
Publisher
Massachusetts Institute of Technology
Abstract
Cell state is established and maintained through the combined action of transcription factors, chromatin regulators and signaling pathways, which all contribute to a transcriptional regulatory circuitry. Embryonic stem (ES) cells are capable of self-renewal and can give rise to nearly all differentiated cell-types, making them an ideal system in which to address the challenges of understanding gene expression and cell state. Valuable insights into the control of cell state have been revealed by recent studies of the ES cell transcriptional regulatory circuitry. Here I present work contributing to the understanding of transcriptional regulatory mechanisms that control ES cell state, specifically signaling pathways and proteins that affect chromatin structure.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, June 2010.
"May 2010." Cataloged from PDF version of thesis.
Includes bibliographical references.
Subjects
Biology.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
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