In Vivo Delivery of Nitric Oxide-Sensing, Single-Walled Carbon Nanotubes
Name
In vivo delivery of nitric.pdf
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655.16 KB
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Author(s)
Iverson, Nicole M.
Strano, Michael S.
Wogan, Gerald N
Date Issued
June 2015
Journal
Current Protocols in Chemical Biology
Publisher
Wiley Blackwell
Citation
Iverson, Nicole M., Michael S. Strano, and Gerald N. Wogan. “In Vivo Delivery of Nitric Oxide-Sensing, Single-Walled Carbon Nanotubes: NO-Sensing Single-Walled Carbon Nanotubes.” Current Protocols in Chemical Biology. Ed. Lara Mahal et al. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. 93–102.
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Author's final manuscript
Abstract
Detection of nitric oxide (NO) in vivo by single-walled carbon nanotubes (SWNT) is based on the fluorescent properties of SWNT and the ability of NO to quench the fluorescence signal. Alterations of the signal can be utilized to detect a small molecule in vivo that has not previously been possible by other assay techniques. The protocols described here explain the techniques used to prepare NO-detecting SWNTs and to administer them to mice by both intravenous and subcutaneous routes. These techniques can also be utilized with other SWNT sensors as well as non-SWNT sensor
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/9780470559277.ch140196
