Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function
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Yoshii-2015-Editorial_ Cell and.pdf
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187.52 KB
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Author(s)
Yoshii, Akira
Constantine-Paton, Martha
Ip, Nancy Y.
Date Issued
June 2015
Journal
Frontiers in Synaptic Neuroscience
Publisher
Frontiers Research Foundation
Citation
Yoshii, Akira, Martha Constantine-Paton, and Nancy Y. Ip. “Editorial: Cell and Molecular Signaling, and Transport Pathways Involved in Growth Factor Control of Synaptic Development and Function.” Frontiers in Synaptic Neuroscience 7 (June 4, 2015).
Version
Final published version
Abstract
Since the discovery of nerve growth factor (NGF) more than a half century ago (Levi-Montalcini and Cohen, 1960), the prototypic neurotrophin family has included brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Neurotrophins bind to the Trk family of receptors, as well as the p75 receptor, to activate multiple intracellular signaling cascades (reviewed by Reichardt, 2006). BDNF receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. The pathway mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays critical roles in circuit development and maintenance. In addition to BDNF, many studies have identified other “growth” or signaling factors in the CNS that play important roles in the development, maintenance, and control of synaptic and circuit function. However, details of the intracellular signaling systems downstream of these events are frequently unexplored. In this Research Topic, we have collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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DOI of Published Version
https://doi.org/10.3389/fnsyn.2015.00008
