A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
Name
ENEURO.0491-21.2022.full.pdf
Description
Published version
Size
3.11 MB
Format
Adobe PDF
Checksum (MD5)
2108422fca7ae9081b5f64a405e4b0e9
Author(s)
Ramadan, Mahdi
Lee, Eric Kenji
de Vries, Saskia
Caldejon, Shiella
Kato, India
Roll, Kate
Griffin, Fiona
Nguyen, Thuyanh V
Larkin, Josh
Rhoads, Paul
Date Issued
September 7, 2022
Journal
eNeuro
Publisher
Society for Neuroscience
Citation
Mahdi Ramadan, Eric Kenji Lee, Saskia de Vries, Shiella Caldejon, India Kato, Kate Roll, Fiona Griffin, Thuyanh V. Nguyen, Josh Larkin, Paul Rhoads, Kyla Mace, Ali Kriedberg, Robert Howard, Nathan Berbesque, Jérôme Lecoq
eNeuro 7 September 2022, 9 (5) ENEURO.0491-21.2022.
Version
Final published version
Abstract
Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here, we dissect how these behavior signals are broadcast to different layers and areas of the visual cortex. To do so, we leveraged a standardized and spontaneous behavioral fidget event in passively viewing mice. Importantly, this behavior event had no relevance to any ongoing task allowing us to compare its neuronal correlates with visually relevant behaviors (e.g., running). A large two-photon Ca2+ imaging database of neuronal responses uncovered four neural response types during fidgets that were consistent in their proportion and response patterns across all visual areas and layers of the visual cortex. Indeed, the layer and area identity could not be decoded above chance level based only on neuronal recordings. In contrast to running behavior, fidget evoked neural responses that were independent to visual processing. The broad availability of visually orthogonal standardized behavior signals could be a key component in how the cortex selects, learns and binds local sensory information with motor outputs. Contrary to behaviorally relevant motor outputs, irrelevant motor signals could project to separate local neural subspaces.
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DOI of Published Version
https://doi.org/10.1523/ENEURO.0491-21.2022
