Resting-State Functional Connectivity of the Subthalamic Nucleus to Limbic, Associative, and Motor Networks
Name
brain.2017.0535.pdf
Description
Published version
Size
550.33 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Guell Paradis, Xavier
Whitfield-Gabrieli, Susan
Triantafyllou, Christina
Mattfeld, Aaron T.
Gabrieli, John D. E.
Geddes, Maiya
Anteraper, Sheeba Rani Arnold
Date Issued
February 2018
Journal
Brain Connectivity
Publisher
Mary Ann Liebert Inc
Citation
Anteraper, Sheeba Arnold et al. "Resting-State Functional Connectivity of the Subthalamic Nucleus to Limbic, Associative, and Motor Networks." Brain Connectivity 8, 1 (February 2018): doi 10.1089/brain.2017.0535 ©2018 Author(s)
Version
Final published version
Abstract
The subthalamic nucleus (STN) is a small structure situated deep in the midbrain that exhibits wide-ranging functionality. In addition to its role in motor control, the STN is considered a hub for synchronizing aspects of emotion and cognition including attention, inhibitory control, motivation, and working memory. Evidence from neuroanatomical tracer studies suggests that the medial, ventromedial, and dorsolateral parts of the STN correspond to limbic, associative, and motor subdivisions, respectively. Although the extent of STN functional anatomical overlap remains unclear, blood oxygenation level dependent imaging of the STN may provide complementary information about the diverse functions of this structure. Methodological limitations in spatial and temporal resolutions, however, have prevented a comprehensive exploration of temporal correlations from the STN to the whole brain. In this study, we optimize spatial (2 mm isotropic) and temporal (TR = 1 s) resolutions to take full advantage of the time series signal-to-noise ratio capabilities of multichannel array coils and simultaneous multislice imaging. We interrogated STN seed-to-voxel resting-state functional MRI connectivity in a group of 30 healthy participants that included the whole brain at high-temporal and spatial resolutions. This analysis revealed STN functional connectivity to limbic, associative, and motor networks. Our findings contribute to the understanding of STN functional neuroanatomy in humans and are clinically relevant for ongoing research in deep brain stimulation.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Martinos Imaging Center (McGovern Institute for Brain Research at MIT)
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1089/BRAIN.2017.0535
