The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
Name
Keating_The MCL-1.pdf
Size
1.25 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Stewart, Michelle L.
Fire, Emiko
Keating, Amy E.
Walensky, Loren D.
Date Issued
August 2010
Journal
Nature Chemical Biology
Publisher
Nature Publishing Group
Citation
Stewart, Michelle L et al. “The MCL-1 BH3 Helix Is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer.” Nature Chemical Biology 6.8 (2010): 595–601. Web.
Version
Author's final manuscript
Abstract
MCL-1 has emerged as a major oncogenic and chemoresistance factor. A screen of stapled peptide helices identified the MCL-1 BH3 domain as selectively inhibiting MCL-1 among the related anti-apoptotic Bcl-2 family members, providing insights into the molecular determinants of binding specificity and a new approach for sensitizing cancer cells to apoptosis.
Description
available in PMC 2011 February 3.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nchembio.391
