Toll-like receptors as developmental tools that regulate neurogenesis during development: an update
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Barak-2014-Toll-like receptors.pdf
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1.41 MB
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Adobe PDF
Checksum (MD5)
f26e989deaf1441719592b2ab48c1978
Author(s)
Barak, Boaz
Feldman, Noa
Okun, Eitan
Date Issued
August 2014
Journal
Frontiers in Neuroscience
Publisher
Frontiers Research Foundation
Citation
Barak, Boaz, Noa Feldman, and Eitan Okun. “Toll-Like Receptors as Developmental Tools That Regulate Neurogenesis During Development: An Update.” Front. Neurosci. 8 (August 28, 2014).
Version
Final published version
Abstract
Neurogenesis, the process of generating new neurons in the brain, fascinates researchers for its promise to affect multiple cognitive and functional processes in both health and disease. Many cellular pathways are involved in the regulation of neurogenesis, a complexity exemplified by the extensive regulation of this process during brain development. Toll-like receptors (TLRs), hallmarks of innate immunity, are increasingly implemented in various central nervous system plasticity-related processes including neurogenesis. As TLRs are involved in neurodegenerative disorders, understanding the involvement of TLRs in neurogenesis may hold keys for future therapeutic interventions. Herein, we describe the current knowledge on the involvement of TLRs in neurogenesis and neuronal plasticity and point to current knowledge gaps in the field.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fnins.2014.00272
